The first Grand Prix event to take place at Misano was in 1980 and the venue has become a permenent fixture on the MotoGP calendar since 2007, after it was completely revised and remodeled. The San Marino Grand Prix was first held at Imola in 1981, has also taken place at Mugello and is now hosted by
Misano as the Gran Premio di San Marino e della Riviera di Rimini.
The local area has produced some great riders. The late Marco Simoncelli was from the nearby town of Cattolica, and Valentino Rossi, Andrea Dovizioso and Marco Melandri all grew up in the region as well.